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The PTEN Family : a subject collection from cold spring harbor perspectives in medicine

Eng, Charis

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서명/저자사항The PTEN Family : a subject collection from cold spring harbor perspectives in medicine / edited by Charis Eng, Joanne Ngeow, Vuk Stambolic.
개인저자Eng, Charis, 1962-
Ngeow, Joanne.
Stambolic, Vuk.
발행사항Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, 2020.
형태사항vii, 357 p. : col. ill. ; 27 cm.
총서명Cold Spring Harbor perspectives in medicine
ISBN9781621823445 (hardcover)
일반주기 A subject collection from Cold Spring Harbor Perspectives in Medicine.
서지주기Includes bibliographical references and index.
요약"PTEN is an important cellular enzyme that is frequently mutated in cancer. In normal cells, it downregulates signaling through the PI3-kinase pathway that controls cell proliferation. When PTEN is mutated, the PI3 pathway becomes overactive, which can contribute to cancer. This volume examines advances in our understanding of the functions of the PTEN protein, its regulation, and how loss of PTEN can promote the development and progression of different cancers"--
해제Provided by publisher.
일반주제명Phosphatases.
분류기호572/.7553
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